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影片主要讲述了搏击天才肖飞为筹集母亲医药费而打黑拳，从此走上了混混之路，后来在奥城拳王段平的鼓励下重新走上正轨，逐渐成为一名拳王的励志故事。荣获金球奖最佳戏剧类电视剧集！荣获艾美奖最佳戏剧类影集选角！萤幕演员公会最佳戏剧类电视剧集！故事延续第三季精采的剧情。西雅图恩典医院因为这些实习医生之间的爱恨情仇，变得更加热闹更有可看性！第三季中格蕾终於摆脱了德瑞克和兽医间的三角恋情，依自己的心意选择了所爱的人。伊兹在丹尼死后一厥不振，甚至想要放弃成为外科医生的梦想。克莉丝汀知道了柏克的秘密后，一直企图帮他掩饰。而乔治和性感火辣的住院医师之间的关係变得更迷离。而艾立克斯竟发现自己还是爱著伊兹！另外，马克为了艾蒂森竟也来到了西雅图恩典医院工作。Meredith和Cristina蜜月归来（买好的机票不好浪费~），Burke已经消失无踪。去年的实习医生Meredith, Cristina, Izzie和Alex，已经获得了正式驻院医生的资格，并且有了自己的跟班，一群初出茅庐，青涩而稚嫩的实习医生。当中，有去年考试不及格的George，还有Meredith素未谋面的妹妹Lexie Grey。今天，他们将要处理一宗三车连环相撞的交通意外，大量的伤者让新来的实习手足无措，目瞪口呆。另一边厢，Derek和Meredith的感情陷入僵局，有可能他们都会和新来的同事有新的感情发展。Bailey对于Callie成为驻院总医生感到气愤，也许她一时三刻还难以接受自己现在要向Callie汇报工作。Richard留任外科主任，仍然是大家的老大~(简介转自YDY)After failing his exam, George reluctantly faces his first day reliving his internship among a sea of fresh faces. Meanwhile, Cristina, Meredith, Izzie and Alex are in charge of their own interns and George is assigned to Meredith.Neither Cristina or Meredith have heard from her exes since the wedding, and they don't seem overly concerned, which astounds Izzie, who is counting every day since she last spoke to George. George asks to talk to Meredith but before he can get her alone, the rest of the new interns show up in the hall and are shooed off by the residents. George gives up and joins the interns. Cristina nicknames him "Bambi," saying he needs to learn how to deal with his new situation.Updated December 17闻瑞泽和母亲两代人共同掩盖的"家庭秘密",最终导致了他婚姻的破裂。老母亲也在被雪华发现这隐瞒了二十年的秘密后旧病复发,撒手人寰.闻瑞泽用男人最大的毅力坚持着自己的事业,用宽广的胸襟包容着妻子的背叛,沉痛的压抑着内心里女儿不为人知的身世.随着更年期的到来他面临着前所未有的生理变化,事业挑战,家庭分裂,他能否挺的过去?他们还能在一起吗?讲述楚逸、江北辰、夏天几位同学为拍古风短剧而发生的校园故事。